Abstract
Isopropylnoradrenalin, cyclic AMP, and dibutyryl-3′,5′-AMP (DB) lower the partial pressure of oxygen (pO2) in the liver and spleen and increase the oxygen consumption of the body. The time course of these two effects for isopropylnoradrenalin and cyclic AMP correlates closely. The increase in heat production was not accompanied by any significant change in the respiratory quotient. The effects of cyclic AMP were not abolished by pempidine or by dihydroergotamine and were only reduced to some degree by propranolol. The effect of catecholamines on pO2 is evidently mediated through an increase in the O2 consumption as a result of the effect of cyclic AMP; the action of cyclic AMP is basically direct, but in vivo it cannot take place through the β adrenoreceptor; the compound 2′,3′-AMP reduces pO2 and also the O2 consumption.
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Kulinskii, V.I., Kovalevskii, A.N. Effect of cyclic nucleotides and of isopropylnoradrenalin on the partial pressure and consumption of oxygen. Bull Exp Biol Med 83, 181–184 (1977). https://doi.org/10.1007/BF00799416
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DOI: https://doi.org/10.1007/BF00799416