Abstract
The content of histamine (by the reaction with orthophthalic aldehyde) and serotonin (by Falk's reaction) in mesenteric mast cells of normal and germfree rats was determined microspectrometrically. Reserpine (10 mg/kg, intramuscularly) was shown not to change the histamine content, whereas the serotonin content was reduced by 50%. Injection of cyclic AMP (3.5 mg/kg, intraperitoneally) caused the serotonin content to be increased by 80% and the histamine content by 280–320%.
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Literature Cited
P. N. Aleksandrov, in: The Microcirculation. Proceedings of the First All-Union Conference on the Microcirculation [in Russian], Moscow (1972), p. 99.
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Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR. Research Laboratory of Experimental Biological Models, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny. Vol. 83, No. 2, pp. 175–177, February, 1977.
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Aleksandrov, P.N., Podoprigora, G.I. & Chernukh, A.M. Fluorimetric determination of histamine and serotonin in mast cells of normal and germfree rats treated with reserpine and cyclic AMP. Bull Exp Biol Med 83, 178–180 (1977). https://doi.org/10.1007/BF00799415
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DOI: https://doi.org/10.1007/BF00799415