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Role of nonspecific oxidases of rat liver microsomes in the breakdown of N1-furanidylpyrimidines

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

N1-(31-Butyrolactono)-5-fluorouracil, N1-(21-furanidyl)-5-trifluoromethyluracil, and N1-(21-furanidyl)-5-fluorouracil are broken down in the rat in vivo with the liberation of free 5-fluorouracil. Rupture of the C−N bond in the molecule of N1-(21-furanidyl)-5-fluorouracil takes place in the liver microsomes. This process is stimulated in the presence of NADPH and is inhibited by SKF-525A. All three furani-dylpyrimidines studied induced differential spectra of type I in the suspension of liver microsomes, evidence of interaction of these substances with cytochrome P-450.

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Authors
  1. D. V. Meiren
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  2. É. L. Urbanovich
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  3. T. N. Sniedze
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  4. Kh. B. Khagi
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  5. A. P. Gilev
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Meiren, D.V., Urbanovich, É.L., Sniedze, T.N. et al. Role of nonspecific oxidases of rat liver microsomes in the breakdown of N1-furanidylpyrimidines. Bull Exp Biol Med 83, 160–162 (1977). https://doi.org/10.1007/BF00799410

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  • DOI: https://doi.org/10.1007/BF00799410

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