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Effect of stimulation and inhibition of erythropoiesis on antibody production and migration of B cells from the bone marrow and spleen in mice

  • Microbiology and Imnunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of stimulation and inhibition of erythropoiesis on the production of antibody-forming cells (AFC) in the spleen and on the migration of B cells from the bone marrow into the spleen was studied in CBA mice. Stimulation of erythropoiesis was shown to increase the number of AFC in the spleen and migration of B cells from the bone marrow into the spleen sharply 1 and 4 days after blood loss. Inhibition of erythropoiesis led to a very small increase in the number of AFC in the spleen 4 and 7 days after transfusion of syngeneic red cells and inhibited migration of B cells from the bone marrow into the spleen. The possible mechanisms of the effect of stimulation and inhibition of erythropoiesis on antibody formation are discussed.

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Authors
  1. V. A. Kozlov
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  2. V. P. Lozovoi
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  3. I. N. Zhuravkin
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Kozlov, V.A., Lozovoi, V.P. & Zhuravkin, I.N. Effect of stimulation and inhibition of erythropoiesis on antibody production and migration of B cells from the bone marrow and spleen in mice. Bull Exp Biol Med 83, 345–347 (1977). https://doi.org/10.1007/BF00799358

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  • DOI: https://doi.org/10.1007/BF00799358

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