Abstract
Indices of the central hemodynamics were studied in puppies aged 18–22 days and 2–3 months and in dogs aged 3–5 years after intravenous injection of synthetic vasopressin (0.8 unit/kg body weight). The pressor effect was strongest in the adult dogs and bradycardia in the puppies aged 18–22 days. The cardiac output was reduced in all animals and the peripheral resistance considerably increased. In adult dogs the external work of the left ventricle and the energy consumption of the heart were increased. In puppies a reduction in the volume velocity of ejection of blood and in the external work of the heart was combined with a smaller increase in energy consumption.
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Brin, V.B. Changes in the systemic hemodynamics produced by vasopressin in dogs during individual development. Bull Exp Biol Med 83, 289–292 (1977). https://doi.org/10.1007/BF00799339
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DOI: https://doi.org/10.1007/BF00799339