Abstract
The primary and secondary immune response was studied in mice in which tolerance was induced by injection of sheep's erythrocytes and cyclophosphamide (CP). In the early stages (from 1 to 8 weeks) after induction the mice were immunized with sheep's erythrocytes either in a single dose of 5·108 cells or in two doses each of 1·106 cells. Both methods of immunization gave equal results in the control animals. In the experimental animals the process of formation and (or) realization of immunological memory was impaired to a greater degree and recovered more slowly than ability to give a primary response.
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Kazaryan, K.A., Tat'yan, M.V., Kirakosyan, S.D. et al. Primary and secondary immune response in animals after spontaneous loss of tolerance. Bull Exp Biol Med 83, 850–852 (1977). https://doi.org/10.1007/BF00798895
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DOI: https://doi.org/10.1007/BF00798895