Abstract
The state of, the barrier-fixing function was studied in germfree and ordinary guinea pigs and rats. After contamination withEscherichia coli 055 (in doses of 5·108 and 10·1010 bacterial cells for subcutaneous and oral administration, respectively) only transient bacteriemia was observed in the ordinary animals in the early stages after infection. Meanwhile the bacteriemia in the germfree animals increased progressively to cause death of the animals in the course of 2–3 days. A reduced fixing and bactericidal power of the regional lymphatic system and of the deep structures of the monocytic-phagocytic system was discovered in the germfree animals. Experimental confirmation of the role of antibodies in the manifestation of the barrier-fixing function was obtained with respect toE. coli. The experiments show the important role of the microbial facotr in the formation of the barrier-fixing function of the body.
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Podoprigora, G.I. Barrier-fixing function in germfree animals. Bull Exp Biol Med 83, 838–841 (1977). https://doi.org/10.1007/BF00798891
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DOI: https://doi.org/10.1007/BF00798891