Abstract
The dynamics of some indices of nitrogen metabolism in the brain was studied in dogs after lethal blood loss and in the postresuscitation period. The investigation showed that the main source of ammonia in the brain during the development of the organism and in the state of clinical death is glutamine. In the recovery period after resuscitation, however, glutamine becomes a remover of ammonia and the main source of ammonia becomes the labile amino groups of proteins.
Similar content being viewed by others
Literature Cited
M. S. Gaevskaya, Biochemistry of the Brain in the Terminal State and during Resuscitation [in Russian], Moscow (1963).
M. S. Gaevskaya and E. A. Nosova, Ukr. Biokhim. Zh., No. 3, 407 (1961).
Z. S. Gershenovich and A. A. Krichevskaya, Biokhimiya, No. 6, 715 (1956).
Z. S. Gershenovich, A. A. Krichevskaya, A. I. Lukash, et al., in: Proceedings of the Third All-Union Conference on Biochemistry of the Nervous System [in Russian], Erevan (1963), p. 91.
L. S. Kaminskii, The Analysis of Clinical and Laboratory Data [in Russian], Leningrad (1959).
V. A. Negovskii, Current Problems in Resuscitation [in Russian], Moscow (1971).
I. A. Oivin, “Statistical analysis of the results of experimental investigations,” in: Trudy Stalingrad. Inst.,4, 4–8 (1957).
A. G. E. Pearse, Histochemistry: Theoretical and Applied, Little, Brown, Boston (1960).
A. I. Silakova, G. P. Trush, and A. Yakovleva, Vopr. Med. Khim., No. 5, 538 (1962).
S. A. Khachatryan, “Resuscitation during fever and certain changes in metabolism and in the endocrine system,” Author's Abstract of Doctoral Dissertation, Erevan (1968).
W. H. Elliott, Biochem. J.,49, 106 (1951).
D. Seligson and H. Seligson, J. Lab. Clin. Med.,38, 324 (1951).
R. Vrba, Nature,176, 117 (1955).
Wu Chung, Arch. Biochem.,106, 402 (1964).
Rights and permissions
About this article
Cite this article
Khachatryan, S.A., Papyan, A.A. Some aspects of ammonia formation in the brain of dying animals and during recovery after resuscitation. Bull Exp Biol Med 83, 814–816 (1977). https://doi.org/10.1007/BF00798882
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00798882