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Biosynthesis of renal prostaglandins in spontaneously hypertensive rats

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The biosynthesis of prostaglandins (PG) E2 and F2α from [14C]arachidonic acid by renal medullary tissue of rats with spontaneous hypertension and of normotensive Wistar rats was investigated at different ages (1.5 and 3.5 months). In animals with spontaneous hypertension the synthesis of PG E2 from arachidonic acid was at a much lower level than in Wistar rats. The biosynthesis of PG F2α in these animals was virtually indistinguishable from normal. No age differences were found in PG formation by the kidneys of rats with spontaneous hypertension, whereas in Wistar rats PG E2 biosynthesis was depressed at the age of 3.5 months.

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Authors
  1. Kh. M. Markov
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  2. I. A. Ivanova
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  3. G. F. Zadkova
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Markov, K.M., Ivanova, I.A. & Zadkova, G.F. Biosynthesis of renal prostaglandins in spontaneously hypertensive rats. Bull Exp Biol Med 83, 780–783 (1977). https://doi.org/10.1007/BF00798871

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  • DOI: https://doi.org/10.1007/BF00798871

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