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Local anesthesia in irradiated animals

  • Phrmacology
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Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments were conducted on animals subjected to X-irradiation. A study was made of the features peculiar to the effect of local anesthetizing agents in various types of anesthesia. As revealed, the effect of decicaine on the cornea of the eye (terminal anesthesia) became intensified during the first hours after the irradiation of the animals (rabbits−1000 r) and reduced by the end of the first 24hr. The initial value of the effect was restored by the third day. The extent of novocain block of the sensitive conductors (conduction anesthesia) is greater in irradiated animals (frog−5000 r) than that in nonirradiated ones. The analgesic effect of anesthetics (novocain, bencaine, mesocaine) weakened during infiltration anesthesia administered to the irradiated animals (guinea pigs−350 r).

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Authors and Affiliations

  1. Division of Experimental Therapy Central Research Institute of Medical Radiology, Ministry of Health of the USSR, Leningrad

    A. V. Lazovskaya

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  1. A. V. Lazovskaya
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Lazovskaya, A.V. Local anesthesia in irradiated animals. Bull Exp Biol Med 55, 173–176 (1964). https://doi.org/10.1007/BF00798825

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  • DOI: https://doi.org/10.1007/BF00798825

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