Skip to main content
SpringerLink
Log in

The action of certain drugs on the respiration of the smooth muscle of blood vessels

  • Phrmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

As experimentally demonstrated, adrenalin and noradrenalin increased the oxygen uptake by the aortic wall in concentrations of 10−5 causing the maximal contraction of the isolated rabbit aortic band. Ephedrine and serotonin, which also caused contraction of the vascular band, had almost no effect on the respoiration of the aortic smooth muscles.

Of the vasodilating substances, euphylline does not change the tissue respiration, sodium nitrite has a tendency to increase the QO2 as compared to control values, whereas papaverine depresses the tissue respiration. There is a parallelism between the capacity of papaverine to depress the adrenalin-induced contraction and reduction of oxygen uptake by the isolated rabbit aortic band in conjoint administration of adrenalin and papaverine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. V. M. Kushko, B. A. Kul'nev, and M. G. Khovanskaya. In: The Metabolism of the Blood Vessel Wall [in Russian], p. 34. Prague, 1961.

  2. F. P. Trinus, Farmakol. i toksikol., 6, 522 (1959).

    Google Scholar 

  3. F. P. Trinus and A. I. Cherkes, Vestn. Akad. Med. Nauk SSSR, 12, 74 (1961).

    Google Scholar 

  4. F. N. Briggs, S. Chernick, and J. L. Chaikoff, J. biol. Chem., 1949, v. 179, p. 103.

    Google Scholar 

  5. R. F. Furchgott and S. Bhadrakom, J. Pharmacol. exp. Ther., 1953, v. 108, p. 129.

    Google Scholar 

  6. R. F. Furchgott, Pharmacol. Rev., 1955, v. 7, p. 183.

    Google Scholar 

  7. C. N. Gillis, J. Pharmacol. exp. Ther., 1959, v. 127, p. 265.

    Google Scholar 

  8. J. E. Kirk, P. G. Efferse, and S. P. Chiang, J. Geront., 1954, v. 9, p. 10.

    Google Scholar 

  9. S. M. Kirpekar and J. J. Lewis, Brit. J. Pharmacol. 1959, v. 14, p. 40.

    Google Scholar 

  10. N. Maier and H. Haimovici, Proc. Soc. exp. Biol. (N. Y.), 1957, v. 95, p. 425.

    Google Scholar 

  11. P. Mandel, In: The Metabolism of the Vascular Wall [in Russian], p. 145. Prague, 1961.

  12. V. Pantesco, J. Viaud, R. Fontaine, et al., C. R. Soc. Biol., 1957, v. 151, p. 1584.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Kiev Medical Institute, Kiev, USSR

    F. P. Trinus

Authors
  1. F. P. Trinus
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Trinus, F.P. The action of certain drugs on the respiration of the smooth muscle of blood vessels. Bull Exp Biol Med 55, 170–172 (1964). https://doi.org/10.1007/BF00798824

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00798824

Keywords

Search

Navigation