Abstract
Isologous serum of mice immunized with rabbit globulin (IARS) was shown to contain a factor inactivating rosette-forming cells (RFC) in vitro from CBA mice immunized with sheep's erythrocytes. If the mice were immunized with sheep's erythrocytes after preliminary injection of IARS, the number of RFC at the peak of the immune response was about 30% of their number in mice receiving normal isologous serum together with sheep's erythrocytes. The decrease in the number of RFC took place on account of cells not containing θ antigen. Passive immunization with IARS did not affect proliferation of antibody-forming cells or synthesis of antibodies against sheep's erythrocytes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
A. Ya. Kul'berg, V. V. Khorobrykh, I. A. Tarkhanova, et al., Byull. Éksp. Biol. Med., No. 6, 73 (1974).
S. A. Simonyan, V. V. Khorobrykh, B. L. Yurin, et al., Byull. Éksp. Biol. Med., No. 6, 715 (1976).
S. Avrameas, B. Tandau, and S. Chuilon, Immunochemistry,6. 67 (1969).
G. Biozzi, C. Stiffel, D. Mouton, et al., Immunology,14, 7 (1968).
N. K. Jerne and A. A. Nordin, Science,140, 405 (1963).
Rights and permissions
About this article
Cite this article
Simonyan, S.A., Chernousova, L.N., Khorobrykh, V.V. et al. Antigen-dependent induction of a nonspecific humoral factor blocking rosette-forming cells in vitro and in vivo. Bull Exp Biol Med 84, 994–996 (1977). https://doi.org/10.1007/BF00798527
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00798527