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Antagonism between L-dopa and apomorphine in their effects on rat behavior

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of apomorphine and L-dopa on the apomorphine behavioral stereotype, on aggressiveness, and on the thresholds of emotional reactivity and aggressiveness induced by painful electrical stimulation, and on orienting motor activity was studied in male albino rats. Whereas the action of these substances given separately was similar in direction, definite antagonism was observed between apomorphine and L-dopa when given together with respect to all behavioral tests. Apomorphine (5 mg/kg), given after L-dopa, increased the dopamine concentration even higher in the forebrain and diencephalon without affecting the noradrenalin level. It is suggested that an increased concentration of functionally active mediator inhibits the activity of postsynaptic receptors sensitive to it.

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Authors
  1. L. Kh. Allikmets
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  2. A. M. Zharkovskii
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  3. É. É. Vasar
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Allikmets, L.K., Zharkovskii, A.M. & Vasar, É.É. Antagonism between L-dopa and apomorphine in their effects on rat behavior. Bull Exp Biol Med 84, 979–981 (1977). https://doi.org/10.1007/BF00798522

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  • DOI: https://doi.org/10.1007/BF00798522

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