Abstract
Phospholipase A and lysolecithin stimulate the reaction of liberation of thromboplastic factor and aggregation of erythrocytes and platelets. Polarographic investigations have shown that these aggregating agents cause absorption of O2 in medium containing platelets, possible evidence of the formation of these conditions of intermediate products of prostaglandin synthesis, namely endoperoxides. Albumin does not prevent the liberation reaction and the absorption of O2 caused by phospholipase and lysolecithin but it completely inhibits their aggregating action. Aspirin, on the other hand, blocks O2 consumption by platelets althoug its action on the aggregating effect of lysolecithin is only very slight. It is suggested that the aggregation of the blood cells is connected with perturbation of the lipid-protein structure of their membranes and not with endoperoxide synthesis.
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Levin, G.Y., Sheremet'ev, Y.A. & Petrov, S.V. Role of endoperoxides of the prostaglandins in platelet aggegation. Bull Exp Biol Med 84, 932–935 (1977). https://doi.org/10.1007/BF00798508
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DOI: https://doi.org/10.1007/BF00798508