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Ischemic preconditioning—do we need more (pharmacological) experiments?

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Conclusion

Preconditioning against myocardial ischemia is potentially a powerful method to protect the human heart. It is obvious that only limited possibilities, e.g., during heart surgery, exist to use short periods of ischemia to elicit the effect. A pharmacological approach, using adenosine A1/A3 analogs or K+ ATP channel openers, seems logical. In view of the gaps in our knowledge on the mechanisms involved, we believe it is prudent to continue basic research in this field before studying ‘preconditioning drugs’ clinically on a larger scale.

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Authors and Affiliations

  1. Cardiochemical Laboratory Thorax Center EE 2371, Erasmus University Rotterdam, P. O. Box 1738, 3000 DR, Rotterdam, The Netherlands

    J. W. de Jong & R. de Jonge

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  1. J. W. de Jong
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  2. R. de Jonge
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de Jong, J.W., de Jonge, R. Ischemic preconditioning—do we need more (pharmacological) experiments?. Basic Res Cardiol 92 (Suppl 2), 48–50 (1997). https://doi.org/10.1007/BF00797209

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