Abstract
Concentration curves of the cytogenetic action of the Soviet antitumor preparation photrin were studiedin 24-h cultures of human lymphocytes with an exposure of 1 h (concentrations from 10 to 70 μg/ml, interval 10 μg/ml). The percentage of aberrant metaphases at the minimal concentration was 19.0 and at the maximal 69.5. The relationship between the concentration of photrin and the number of damaged chromosomes per 100 cells within the range of concentrations studied was described by the equation
where Y is the number of damaged chromosomes per 100 cells and c the concentration of photrin. The main types of chromosomal aberrations were single and paired fragments and chromatid exchanges. With respect to the type and frequency of the cytogenetic lesions induced b it, photrin resembles the known preparation thioTEPA and its is a typical alkylating mutagen.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
N. P. Bochkov, Vestn. Akad. Med. Nauk SSSR, No. 1, 55 (1973).
N. P. Dubinin and E. G. Saprykina, Dokl. Akad. Nauk SSSR,156, No. 4, 956 (1964).
N. V. Pankova, Genetika, No. 6, 62 (1967).
T. G. Selezneva and Yu. V. Seleznev, Tsitologiya i Genetika, No. 3, 244 (1973).
A. G. Sinkus, Genetika, No. 10, 149 (1969).
F. Vogel and P. Jager, Humangenetik,7, 287 (1969).
Rights and permissions
About this article
Cite this article
Azhaev, S.A. Cytogenetic action of the antitumor photrin in cultures of human lymphocytes. Bull Exp Biol Med 78, 1075–1076 (1974). https://doi.org/10.1007/BF00796673
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00796673