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A comparative investigation of the action of preparations from the group of chlorethylamines and ethyleneimines on experimental homo- and heterotransplanted tumors

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The author studied the effect of some antiblastic chemotherapeutic preparations on the growth of mouse tumors (Crocker's sarcoma, cancers RSM and RMZh of the mammary gland, and sarcoma 298) and rabbit Brown-Pearce tumor in heterotransplantation. Mouse turnors were inoculated into three- and four-week-old rats, and rabbit tumors were inoculated into rats and mice. Cortisone was administered to the recipient animals. Therapeutic experiments were conducted on homotransplants of the same tumors. It was shown that the horno- and the heterotransplanted tumors were approximately identical in sensitivity to chemotherapeutic preparations investigated (embichin, sarcolysin, thio-TEPA, etc.).

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Author information

Authors and Affiliations

  1. Laboratory for the Experimental Chemotherapy of Tumors of the Institute of Experimental and Clinical Oncology, Moscow

    A. M. Garin

  2. Laboratory of Turnor Strains of the Institute of Experimental and Clinical Oncology, Moscow

    A. M. Garin

Authors
  1. A. M. Garin
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Additional information

Yu.M. Vasil'ev, our elder scientific coworker, took part in the direction of the work.

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Garin, A.M. A comparative investigation of the action of preparations from the group of chlorethylamines and ethyleneimines on experimental homo- and heterotransplanted tumors. Bull Exp Biol Med 50, 714–717 (1961). https://doi.org/10.1007/BF00796045

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  • DOI: https://doi.org/10.1007/BF00796045

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