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Study of the distribution and catabolism of homologous antibodies in the animal organism

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The passive hemagglutination reaction after Boyden and the complement fixation reaction in 50% hemolysis on cold were used to study the distribution and catabolism of homologic antibodies in the body of a healthy, nonimmune rabbit in an early period after passive immunization. It has been found that the maximum level of antibodies of the organs under investigation is observed 6 h after an intravenous injection of antibodies, the largest number of antibodies being discovered in the spleen, liver, and lymphatic glands, which is evidence of an active part taken by these organs in the catabolism of immune globulins.

It has been found that in the liver and spleen, as distinct from other organs and blood serum, the greatest titer of antibodies is determinable in a fraction which is close in mobility of the β-globulins of serum. This gives one reason to suppose the existence of a selective fication by the above-mentioned organs of antibodies with the electrophoretic mobility of β-globulins.

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Literature Cited

  1. S. Ya. Kaplanskii, O. B. Kuzovleva, and V. D. Uspenskaya, Biokhimiya, No. 4 (1956), p. 469.

    Google Scholar 

  2. A. P. Konikov, Zh. Mikrobiol., No. 1 (1953), p. 57.

    Google Scholar 

  3. L. Anigstein, D. M. Whitney, and W. Barnes, Tex. Rep. Biol. Med., Vol. 12 (1954), p. 3.

    Google Scholar 

  4. W. Boyd, Fundamentals of Immunology [Russian translation], Moscow (1949).

  5. S. V. Boyden, J. Exp. Med., Vol. 93 (1951)., p. 107.

    Google Scholar 

  6. F. M. Burnet, Integrity of the Organism and Immunity [Russian translation], Moscow (1964).

  7. L. Demling, H. Kinzlmeir, and N. Z. Henning, Ges. Exp. Med., Vol. 122, No. 416 (1954).

  8. M. Heidelberger and F. E. Kendall, J. Exp. Med., Vol. 62 (1935), p. 697.

    Google Scholar 

  9. J. H. Humprey and A. S. McFarlane, Biochem. J., Vol. 57 (1954), p. 195.

    Google Scholar 

  10. E. Illes and L. Balla, Acta Vet. Acad. Sci. Hung., Nos. 2–3 (1956), p. 201.

    Google Scholar 

  11. O. H. Lowry, N. J. Rosbrough, A. L. Farr et al., J. Biol. Chem., Vol. 175 (1951), p. 265.

    Google Scholar 

  12. K. M. Stevens, L. Gray, and M. S. Schwartz, Am. J. Physiol., Vol. 175 (1953), p. 147.

    Google Scholar 

  13. W. H. Taliaferro and D. W. Talmage, J. Infect. Dis., Vol. 99 (1956), p. 21.

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Kursk Medical Institute, Moscow

    D. N. Evnin

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  1. D. N. Evnin
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Evnin, D.N. Study of the distribution and catabolism of homologous antibodies in the animal organism. Bull Exp Biol Med 62, 1146–1149 (1966). https://doi.org/10.1007/BF00795462

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  • DOI: https://doi.org/10.1007/BF00795462

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