Summary
The effects of transient changes in coronary transmural pressure on the coronary vasomotor tone was studied in 23 anesthetized dogs. Increases and decreases of the coronary transmural pressure were obtained by constrictions of various duration (2 to 20 s) of the descending thoracic aorta.
The maneuvers were performed in animals with intact cardiac innervation, with the vagi sectioned and with vagal section together with β-blockade. In the absence of β-blockade the increase in the transmural pressure caused a transient increase in the coronary vasomotor tone attributable to a myogenic contractile response and the extravascular compression. This contractile response was not observed when the transmural pressure was increased in the presence of high vasomotor tone after β-blockade. In all animals a transient hyperemia was seen with its peak 8 to 12 s after the release of the aortic constriction. Since its timing and amplitude were independent of the duration of the constriction, the metabolic effect of the increased ventricular afterload, although it may have contributed to the decrease of the coronary resistance, cannot be considered entirely responsible for the hyperemia, which was otherwise compatible with a myogenic vasodilatory response triggered by the sudden fall of the transmural pressure at the release of the constriction.
It is concluded that, in the coronary circulation of the intact dog, transient changes in transmural pressure can induce vasomotor responses in which myogenic and metabolic mechanisms combine together in regulating the coronary flow. Changes in extravascular compression can also affect the flow when the experimental maneuver implies changes in the diastolic left ventricular pressure and volume. With the present experimental procedure the myogenic responses have been evidenced when the metabolic factors would have been expected to produce opposite changes in the vasomotor tone.
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References
Altman PL, Dittmer DS (1964) Biology Data Book. Federation of American Society of Experimental Biology, Washington DC, pp 259–263
Bayliss WM (1902) On the local reactions of the arterial wall to changes of internal pressure. J Physiol (Lond) 28:220–231
Bassenge E, Heusch G (1990) Endothelial and neuro-humoral control of coronary blood flow in health and disease. Rev Physiol Biochem Pharmacol 116:77–164
Bassenge E, Holtz J, Busse R, Pohl U (1986) Potential vasomodulatory role of the endothelium in neuronal and humoral coronary regulation. Funktionsanalyse biologischer Systeme 17:63–74
Bellamy RF (1980): Calculation of coronary vascular resistance. Cardiovasc Res 14:261–269
Berne RM (1964) Regulation of coronary blood flow. Physiol Rev 44:1–29
Berne RM (1980) The role of adenosine in the regulation of coronary blood flow. Cir Res 47:807–813
Borgstrom P, Grande PO, Londbom L (1981) Responses of single arterioles in vivo in cat skeletal muscle to change in arterial pressure applied at different rates. Acta physiol Scand 113:207–212
Brooker G (1953) Oscillation of cyclic adenosine monophosphate concentration during the myocardial contraction cycle. Science 182:933–934
Burton AC (1951) On the physical equilibrium of small blood vessels. Am J Physiol 164:319–329
Burton AC (1954) Relation of structure to function of the tissues of the wall of blood vessels. Physiol Rev 34:619–642
Dankelman J, Spaan JAE, Van der Ploeg CPB, Vergroesen I (1989) Dynamics responses of the coronary circulation to a rapid change in its perfusion in the anaesthetized goat. J Physiol 419:703–715
Di Lavore P, Gattullo D, Guiot C, Losano G, Mary DASG, Vacca G, Vono P (1988) Effect of tachycardia and constriction of left cizcumflex artery on coronary flow and pressure in anesthetized dogs. J Physiol 406:469–481
Dodge HT, Kennedy YM, Peterson YL (1973) Quantitative angiographic methods in the evaluation of valvular heart disease. Prog Cardiovasc Dis 16:1–23
Dole WP (1987) Autoregulation of the coronary circulation. Prog Cardiovasc Dis 29:293–323
Dole WP, Nuno DW (1986) Myocardial oxygen tension determines the degree and pressure range of coronary autoregulation. Circ Res 59:202–215
Driscol TE, Moir TW, Eckstein RW (1964) Autoregulation of coronary blood flow: effect of intrarterial pressure gradients. Circ Res 15:103–111
Driscol TE, Moir TW, Eckstein RW (1964) Vascular effect of changes in perfusion pressure in the non-ischemic and ischemic heart. Circ Res 14/15, suppl. I:94–102
Dubè GP, Sadick N, McHale PA, Greenfield JC (1986) A 400 msec diastolic coronary artery occlusion (DCAO) decreases diastolic coronary vascular resistance index (DCVRI) in the same beat by a non-metabolic mechanism. Fed Proc 45:533p
Eikens E, Wilcken DEL (1973) Myocardial reactive hyperemia and coronary vascular reactivity in the dog. Cir Res 33:267–274
Eikens E, Wilcken DEL (1974) Reactive hyperemia in the dog heart: effects of temporarily restricting arterial inflow and of coronary occlusions lasting one and two cardiac cycles. Circ Res 35:702–712
Feigl EO (1983) Coronary Physiology. Physiol Rev 63:1–205
Fossel ET, Morgan HE, Ingwall JS (1980) Measurements of changes in high-energy phosphates in the cardiac cycle31P nuclear magnetic resonance. Proc Natl Acad Sci USA 77:3654–3658
Gattullo D, Dalla Valle R, Linden RJ, Losano G, Pagliaro P (1994) Increases in coronary intravascular pressure during maximal coronary vasodilation in the anaesthetized dog. Cardiology.84:89–98
Gattullo D, Linden RJ, Losano G, Pagliaro P, Westerhof N (1993) Ventricular distension and diastolic coronary blood flow in the anaesthetized dog. Basic Res Cardiol 88:340–349
Giles RW, Wilcken DEL (1977) Reactive hyperemia in the dog heart: evidence for a myogenic contribution. Cardiovasc Res 11:64–73
Heusch G, Yoshimoto N (1983) Effects of cardiac contraction on segmental coronary resistance and collateral perfusion. Int J Microcirc 2:131–141
Hoffman JIE, Spaan JAE (1990) Pressure-flow relations in coronary circulation. Physiol Rev 70:331–390
Johnson PC (1974) The microcirculation and local humoral control of the circulation. In: Cardiovascular Physiology, AC Guyton and CE Jones eds. Baltimore: University Park Press, pp 163–195
Kuo L, Chilian WM, Davis MJ (1991) Interaction of felow and pressure-induced responses in porcine coronary resistance vessels. Am J Physiol 261:H1706–1715
Kuo L, Davis MJ, Chilian WM (1988) Myogenic activity in isolated subepicardial and subendocardial coronary arterioles. Am J Physiol 255:H1558–H1562
Kuo L, Davis MJ, Chilian WM (1990) Endothelium-dependent, flow-induced dilation of isolated coronary arterioles. Am J Physiol 259:H1063–H1070
McHale PA, Dubè GP, Greenfield JC (1987) Evidence for myogenic vasomotor activity in the coronary circulation. Prog Cardiovasc Dis 30:139–146
Mosher BA, Ross J, McFate PA, Shaw RF (1964) Control of coronary blood flow by an autoregulatory mechanism. Circ Res 14:250–259
Schwartz GG, McHale PA, Greenfield JC (1982) Hyperemic response of the coronary circulation to brief diastolic occlusion in the conscious dog. Circ Res 50:28–37
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The experiments were conducted according to the ethic protocol indicated by the Italian Government Act DL n. 116 of January 27, 1992 on the protection of animals used in scientific experiments.
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Gattullo, D., Linden, R.J., Losano, G. et al. Transient effects of quick changes in myocardial metabolism and perfusion pressure on coronary vasomotor responses. Basic Res Cardiol 89, 341–353 (1994). https://doi.org/10.1007/BF00795202
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DOI: https://doi.org/10.1007/BF00795202