Summary
An attempt was made to arrest mitosis of the epithelial cells of the mammary glands, vagina and uterus of sexually mature female mice by castration and the subsequent deprivation of food estrogens. In control castrated animals the mitotic activity in the epithelium of the mammary glands disappears and it decreases considerably in the vaginal and uterine epithelium. After 3 days of starvation the mitotic activity remains high in the vaginal and uterine epithelium of control intact animals. In the castrated animals left without food for 3 days mitosis disappeared entirely in the vaginal epithelium and decreased considerably in the uterine epithelium (in comparison with control castrated animals). Statistical treatment confirmed the authenticity of these results.
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Laguchev, S.S., Kargina-Terent'eva, R.A. Ovarian hormones as a factor essential to mitosis of epithelial cells of reproductive organs. Bull Exp Biol Med 56, 1131–1133 (1963). https://doi.org/10.1007/BF00792994
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DOI: https://doi.org/10.1007/BF00792994