Summary
A study was made of the change in the blood serum lysozyme content of rabbits immunized with the following vaccine preparations: crude toxoid, chemical divaccine, and microbial tetravaccine against intestinal infections, sorbed diphtheria toxoid, gangrene-tetanus tetratoxoid.
It was shown that vaccination caused a distinct reduction of the blood lysozyme content. Restoration of the lysozyme titer to the initial level was observed to occur in most cases not earlier than 20 days after the preparation had been given. There was a direct relationship between the immunizing power of the vaccine (its aount, antigenic activity, and number of administrations) and the extent of the reduction of the lysozyme titer. A definite correlation was noted between the blood content of specific antibodies and lysozyme: the time for the greatest antibody titer rise corresponded to the periods of least lysozyme content.
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D. F. Pletsityi, A. M. Monaenkov, Yu. B. Ostrovskii, et al., Zh. mikrobiol., No. 8, p. 112 (1962).
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Pletsityi, D.F., Fidel'man, E.S. Immunogenesis and nonspecific factors of natural resistance. Bull Exp Biol Med 56, 1117–1120 (1963). https://doi.org/10.1007/BF00792990
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DOI: https://doi.org/10.1007/BF00792990