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Effect of cardiac glucosides on the coronary circulation and the oxygen absorption by the heart in experimental myocardial infarction

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made of the effect produced by strophanthin, erysimin and digitoxin on the coronary circulation, cardiac oxygen absorption, ECG and toxicity in experimental myocardial infarction. Cardiac glucosides, given in therapeutic doses (0.05–0.1 c.u./kg), in conditions of coronary insufficiency induced by ligation of the left descending coronary artery, increased the volume velocity of the coronary circulations and cardiac oxygen absorption, normalized the EEG and possessed an anti-arrhythmic action. Erysmin and digitoxin produced a more marked effect on the coronary circulation than strophanthin. The toxicity of cardiac glucosides increased considerably in experimental myocardial infarction; during the action of these preparations the transmission of excitation from the vagus nerves to the cardiac muscle is facilitated.

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Authors and Affiliations

  1. Department of Pharmacology, Order of Lenin I. M. Sechenov First Moscow Medical Institute, Moscow, USSR

    E. A. Veselova

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  1. E. A. Veselova
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Veselova, E.A. Effect of cardiac glucosides on the coronary circulation and the oxygen absorption by the heart in experimental myocardial infarction. Bull Exp Biol Med 56, 1105–1109 (1963). https://doi.org/10.1007/BF00792986

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  • DOI: https://doi.org/10.1007/BF00792986

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