Skip to main content
SpringerLink
Log in

Lipolytic activity of adipose tissue in experimental alloxan diabetes

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments were staged in vitro. In alloxan diabetes lipolysis of adipose tissue in the incubation medium without glucose is either unchanged or reduced.

In the presence of glucose in the incubation medium the output of free nonesterified fatty acids (NEFA) from the adipose tissue increases by comparison with the adipose tissue of normal animals placed in the same experimental conditions; this is the result of a lessened inhibition by glucose of lipolytic activity in the adipose tissue of diabetic animals. In other words, in connection with disturbed glucose metabolism in the adipose tissue during diabetes there is a derangement of triglyceride synthesis and a relative prevalence of lipolysis. This may be one of the causes of increased blood NEFA content in diabetes mellitus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. N. K. Davtyan, Byull. éksper. biol., 11, 63 (1962).

    Google Scholar 

  2. S. M. Leites and Chou-Su, Vopr. med. khimii, 3, 289 (1962).

    Google Scholar 

  3. A. M. Lobanova, Proceedings of an Annual Scientific Session of the All-Union Institute of Experimental Endocrinology [in Russian], p. 53. Moscow (1961).

  4. D. N. Sakhibov, Izv. AN Uzbek. SSR, Ser. med., 2, 30 (1959).

    Google Scholar 

  5. E. L. Bierman, V. P. Dole, and T. N. Roberts, Diabetes, Vol. 6, p. 475 (1957).

    Google Scholar 

  6. R. M. Buckle, D. Rubinstein, E. McGarry, et al., Endocrinology, Vol. 69, p. 1009 (1961).

    Google Scholar 

  7. V. P. Dole, J. clin. Invest., Vol. 35, p. 150 (1956).

    Google Scholar 

  8. R. S. Gordon, Jr., J. clin. Invest., Vol. 36, p. 810 (1957).

    Google Scholar 

  9. R. S. Gordon, Jr., and A. Cherkes, Proc. Soc. exp. Biol. (N. Y.), Vol. 97, p. 150 (1958).

    Google Scholar 

  10. B. C. Munkner, Scand. J. clin. Lab. Invest., Vol. 11, p. 388 (1959).

    Google Scholar 

  11. M. S. Raben and C. H. Hollenberg, J. clin. Invest., Vol. 39, p. 435 (1960).

    Google Scholar 

  12. J. Wenkeova and J. Pav, Nature, Vol. 184, p. 1147 (1959).

    Google Scholar 

  13. E. Wertheimer and E. Shafrir, Recent Prog. Hormone Res., Vol. 16, p. 467 (1960).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathological Physiology, Central Postgraduate Medical Institute, Moscow

    N. K. Davtyan

Authors
  1. N. K. Davtyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Davtyan, N.K. Lipolytic activity of adipose tissue in experimental alloxan diabetes. Bull Exp Biol Med 56, 1078–1080 (1963). https://doi.org/10.1007/BF00792978

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00792978

Keywords

Search

Navigation