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Investigation of the “valency” of antibodies by means of azoproteins

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The “valency” of antibodies was studied by the method of exhaustion of antisera against mono-and diazoproteins, and subsequent cross reactions both with the antibodies left over in the supernatant fluid of the serum and with the “precipitating” and “nonprecipitating” antibodies isolated from the precipitate.

It was proved that the antibodies interact with the antigens as multivalent compounds.

The “valency” determined with regard to the azoproteins is dependent upon the number of groups introduced.

Thus, “bivalent” antibodies correspond to monoazoproteins and “trivalent” ones to diazoproteins.

The “valency” of antibodies is, evidently, determined by the structural similarity of the heterologous and the immunizing antigens as well as by the less complete specific conformity between the individual structural peculiarities of the antigen and its antibody.

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Authors
  1. A. I. Nikolaev
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Additional information

From the Tashkent Pharmaceutical Institute (Director-Docent M. A. Azizov)

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Nikolaev, A.I. Investigation of the “valency” of antibodies by means of azoproteins. Bull Exp Biol Med 48, 1518–1523 (1959). https://doi.org/10.1007/BF00792748

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  • DOI: https://doi.org/10.1007/BF00792748

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