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Effect of sympathomimetic agents and dopa on the ultrastructure of the nervous apparatus of the heart

  • Morphology and Pathomorphology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

After a single injection of noradrenalin or dopa into albino rats noradrenalin was incorporated into adrenergic axons of the heart and deposited as granules in the small synaptic vesicles measuring about 30 nm in diameter. In this way adrenergic axons could be distinguished from cholinergic. Cholinergic axons were more numerous than adrenergic in the atria. Adrenergic terminals come into very intimate contact with cholinergic terminals and also withcapillary endothelial cells and muscle cells of the myocardium. It is postulated that adrenergic fibers may act on heart muscle in three ways: by means of presynaptic inhibition through cholinergic axons, by a humoral mechanism, and directly on the muscle cells of the myocardium.

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Literature Cited

  1. V. V. Glagoleva and Yu. S. Chechulin, Ultrastructural Basis of Disturbance of the Function of Heart Muscle. Atlas [in Russian], Moscow (1968).

  2. V. A. Shakhlamov, Capillaries [in Russian], Moscow (1971).

  3. F. E. Bloom and R. J. Barrnett, Nature,210, 599 (1966).

    Google Scholar 

  4. G. Burnstock and P. M. Robinson, Circulat. Res.,21, Suppl. 3, 43 (1967).

    Google Scholar 

  5. B. Ehinger, B. Falck, and B. Sporrong, Z. Zellforsch.,107, 508 (1970).

    Google Scholar 

  6. R. Hadek and P. J. Talso, J. Ultrastruct. Res.,17, 257 (1967).

    Google Scholar 

  7. L. L. Iversen, Uptake and Storage of Noradrenaline in Sympathetic Nerves, Cambridge Univ. Press, New York (1967).

    Google Scholar 

  8. T. Iwayma and J. B. Furness, J. Cell. Biol.,48, 699 (1971).

    Google Scholar 

  9. L. M. Napolitano, T. Cooper, V. L. Willman, et al., Circulation,29, Suppl., 81 (1964).

    Google Scholar 

  10. A. N. Novi, Anat. Rec.,160, 123 (1968).

    Google Scholar 

  11. L. T. Potter, Circulat. Res.21, 13 (1967).

    Google Scholar 

  12. A. D. Smith, W. P. De Potter, E. J. Moerman, et al., Cell Tissue Kinet.,2, 547 (1970).

    Google Scholar 

  13. J. P. Tranzer and H. Thoenen, Experientia24, 484 (1968).

    Google Scholar 

  14. K. Uchizono, Jap. J. Physiol.,14, 587 (1964).

    Google Scholar 

  15. D. E. Wolfe and L. T. Potter, Anat. Rec.,145, 301 (1963).

    Google Scholar 

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Authors
  1. S. P. Semenov
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Semenov, S.P. Effect of sympathomimetic agents and dopa on the ultrastructure of the nervous apparatus of the heart. Bull Exp Biol Med 82, 1730–1733 (1976). https://doi.org/10.1007/BF00790401

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  • DOI: https://doi.org/10.1007/BF00790401

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