Abstract
The α-adrenergic blocking drug phentolamine was injected into male rats 1 h before resection of 70% of the liver and again 24 h after the operation. Phentolamine inhibited mitotic activity of the regenerating liver. Two injections of propranolol, a β-adrenergic blocking drug, at the same times caused an increase in mitotic activity. It was concluded that adrenalin, which excites β-adrenergic receptors, may inhibit regeneration. By its action through α-adrenergic receptors, however, adrenalin stimulates this process.
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Vunder, P.A., Vunder, V.P. & Andronova, T.A. Effect of adrenergic receptor blocking agents on mitotic activity of the regenerating liver. Bull Exp Biol Med 82, 1718–1720 (1976). https://doi.org/10.1007/BF00790397
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DOI: https://doi.org/10.1007/BF00790397