Abstract
The insulin sensitivity of subcutaneous adipose tissue taken by biopsy from 11 healthy women and from 10 women with normal weight but recently diagnosed as suffering from diabetes mellitus was investigated. Unlike in the healthy subjects, no increase in the intensity of glucose oxidation to CO2 was produced in the adipose tissue of the diabetics by insulin in a concentration of 50 microunits/ml, and the synthesis of glycogen from glucose was not increased by insulin in concentrations of 50 and 100 microunits/ml. The decrease in the sensitivity of the various pathways of glucose metabolism in adipose tissue to insulin in diabetics points to the possibility of a disturbances of the interaction between insulin and the cell membrane in this disease.
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Yaroshevskii, Y.A. Action of insulin on adipose tissue of diabetics. Bull Exp Biol Med 82, 1650–1652 (1976). https://doi.org/10.1007/BF00790374
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DOI: https://doi.org/10.1007/BF00790374