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Effect of cytostatic agents on development of the febrile reaction to injection of bacterial pyrogen

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The development of the febrile reaction to injection of bacterial lipopolysaccharide (pyrogenal) in rabbits after preliminary treatment with actinomycin D and cortisone was studied. This treatment did not change the reactivity of the temperature regulating centers of the rabbits to endogenous pyrogen. After intravenous injection of the bacterial pyrogen the febrile reaction, was considerably shortened, and after intracisternal injection of the pyrogen the reaction was sharply inhibited. These results indicate an important role of polymorphonuclear leukocytes and of endogenous pyrogen formation by these cells in the mechanism of fever in response to the action of bacterial pyrogen.

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Authors
  1. A. V. Sorokin
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  2. O. M. Efremov
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  3. O. A. Él'kina
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  4. E. G. Rybakina
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  5. I. K. Ukhanova
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Sorokin, A.V., Efremov, O.M., Él'kina, O.A. et al. Effect of cytostatic agents on development of the febrile reaction to injection of bacterial pyrogen. Bull Exp Biol Med 82, 1640–1643 (1976). https://doi.org/10.1007/BF00790371

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  • DOI: https://doi.org/10.1007/BF00790371

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