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Effect of mustine (HN2) and its monofunctional analogue (HN1) on template activity of chromatin and DNA in an RNA-polymerase system in vitro

  • Experimental Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Mustine inhibits the template activity of chromatin and DNA in an RNA-polymerase system in vitro much more strongly than its monofunctional analogue. Chromatin is more sensitive to the action of mustine than is deproteinized DNA. However, the template activity of DNA is reduced to a greater degree by the action of the monofunctional analogue of mustine than is that of chromatin. The mechanism of inhibition of the template activity of chromatin by mustine is probably connected with the ability of the compound to form DNA-protein cross-linkages in the chromatin structure.

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Authors and Affiliations

  1. Laboratory of Biophysics, Institute of Medical Genetics, Academy of Medical Sciences of the USSR, Moscow

    N. M. Mironov & P. I. Tseitlin

Authors
  1. N. A. Sokolov
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  2. E. G. Piker
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  3. N. M. Mironov
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  4. P. I. Tseitlin
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Additional information

Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 8, pp. 106–109, August, 1975.

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Sokolov, N.A., Piker, E.G., Mironov, N.M. et al. Effect of mustine (HN2) and its monofunctional analogue (HN1) on template activity of chromatin and DNA in an RNA-polymerase system in vitro. Bull Exp Biol Med 80, 975–978 (1975). https://doi.org/10.1007/BF00789286

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  • DOI: https://doi.org/10.1007/BF00789286

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