Abstract
The order of arrangement of drugs by diminishing inhibitory effect on serotonin (5-HT) uptake by platelets corresponds to the order of their distribution by diminishing thymo-analeptic action: chlorimipramine > imipramine > amitriptyline > desipramine-nortriptyline-chlorprothixene > chlorpromazine > norprothixene > prothixene-promazine. The change in the effect of the compound on 5-HT uptake by platelets caused by introduction of a chlorine atom into its structure or by demethylation of the compound is largely determined by the chemical structure of the original compound.
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Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 8, pp. 74–77, August, 1975.
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Oksenkrug, G.F. Effect of prothixene and allied compounds on serotonin uptake by human blood platelets. Bull Exp Biol Med 80, 941–943 (1975). https://doi.org/10.1007/BF00789276
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DOI: https://doi.org/10.1007/BF00789276