Skip to main content
SpringerLink
Log in

Changes in liver lysosomes of rats with chronic toxic hepatitis

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Permeability of the lysosomal membranes and the subcellular distribution of acid hydrolases were investigated in rats with chronic hepatitis induced by inhalation of CCl4 and during repair of the liver after injury. Until 14 days after the last inhalation of CCl4 no sign of restoration of the parameters studied to normal was observed: changes in the stability of the lysosomal membranes persisted and a redistribution of acid hydrolases was observed. This last effect is associated with the processes of both injury and repair of the liver.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. A. E. Kondakova, T. A. Korolenko, G. M. Vakulin, et al., Tsitologiya, No. 11, 1382 (1973).

    Google Scholar 

  2. E. I. Tsilli, V. G. Titova, A. E. Kondakova, et al., Farmakol. i Toksikol., No. 6, 724 (1973).

    Google Scholar 

  3. M. U. Dianzani, F. U. Baccino, and J. S. Rita, Acta Anat. (Basel),56, 152 (1969).

    Google Scholar 

  4. C. De Duve, B. C. Pressman, et al., Biochem. J.,60, 604 (1955).

    PubMed  Google Scholar 

  5. J. F. R. Kerr, in: Lysosomes in Biology and Pathology, Edited by J. T. Dingle and H. B. Fell, Vol. 3, Amsterdam (1973), p. 365.

  6. J. L. Mego, in: Lysosomes in Biology and Pathology, Edited by J. T. Dingle and H. B. Fell, Vol. 3, Amsterdam (1973), p. 138.

  7. A. R. Poole, in: Lysosomes in Biology and Pathology, Edited by J. T. Dingle and H. B. Fell, Vol. 3, Amsterdam (1973), p. 303.

  8. N. Rabinovici and E. Wiener, Gastroenterology,40, 416 (1961).

    PubMed  Google Scholar 

  9. V. E. Rahman, J. F. Howe, et al., Biochim. Biophys. Acta,146, 484 (1967).

    PubMed  Google Scholar 

  10. G. Ugazio et al., Biochem. J.,90, 109 (1964).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Central Research Laboratory, Novosibirsk Medical Institute, USSR

    T. A. Korolenko & V. G. Titova

Authors
  1. T. A. Korolenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. G. Titova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 8, pp. 50–53, August, 1975.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Korolenko, T.A., Titova, V.G. Changes in liver lysosomes of rats with chronic toxic hepatitis. Bull Exp Biol Med 80, 910–913 (1975). https://doi.org/10.1007/BF00789268

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00789268

Key words

Search

Navigation