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Inhibition of compensatory hypertrophy of the thyroid gland by thyroxine in rats of different ages

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It was shown in male rats aged 2–2.5, 8–10, and 14–16 months that the inhibitory effect of the same dose (expressed per unit of body weight) of thyroxine on compensatory hypertrophy of the thyroid gland increases with age. It is postulated that the threshold of sensitivity of the hypothalamic-pituitary-thyroid system to homeostatic inhibition decreases with age.

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Authors and Affiliations

  1. Laboratory of Endocrinology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the USSR, Leningrad

    L. M. Bershtein

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  1. L. M. Bershtein
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Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 8, pp. 31–33, August, 1975.

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Bershtein, L.M. Inhibition of compensatory hypertrophy of the thyroid gland by thyroxine in rats of different ages. Bull Exp Biol Med 80, 886–888 (1975). https://doi.org/10.1007/BF00789261

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  • DOI: https://doi.org/10.1007/BF00789261

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