Summary
The author attempted to obtain specific antitumor sera on the basis of the phenomenon of an artificially created immunological tolerance. It was shown that only an insignificant degree of immunological approximation can be attained in rabbits with respect to heterologous mice antigens by administering the latter to the embryos, especially when this is supplemented by a subsequent inoculation at an early period of extra-uterine life. This immunological approximation is incomplete and is manifested only by an insignificant reduction in the formation of normal antibodies, inadequate for obtaining “pure” monospecific and antitumor sera to Ehrlich's mouse carcinoma. The antisera to the Ehrlich's carcinoma obtained on the basis of acquired immunological tolerance were more specific than those derived by the usual method of immunization in control rabbits.
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Mol'kov, Y.N. The production of specific sera to Ehrlich's mouse carcinoma on the basis of the phenomena of acquired immunological tolerance. Bull Exp Biol Med 49, 191–194 (1960). https://doi.org/10.1007/BF00788789
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DOI: https://doi.org/10.1007/BF00788789