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The deliberate cultivation of antitumor properties in bacteria

  • Microbiology and Immunity
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments were performed with the cultures ofProteus vulgaris andBacillus pyocyaneus, the initial strains of which did not posses natural antitumor properties.

These bacteria were cultured for a long period in a medium in which Crocker's sarcoma cells formed the source of nutritive substances. This resulted in the appearance of certain substances among the metabolites of the bacteria able to selectively depress the development and the growth of Crocker's sarcoma in mice.

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Literature Cited

  1. O. E. Vyazov, Immunology of Normal and Malignant Tissues, p. 254. Moscow, 1956 [In Russian].

  2. G. F. Gauze, Antibiotics, p. 103. Medgiz, 1956 [In Russian].

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Authors and Affiliations

  1. Leningrad

    I. I. Oleinik & V. N. Yagodinskii

Authors
  1. I. I. Oleinik
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  2. V. N. Yagodinskii
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Additional information

The authors express their deep gratitude to Prof. A. A. Sinitskii, Corresponding Member AMN SSSR M. M. Maevskii and Honored Scientist Prof. P. N. Kashkin, who acted as scientific consultants in the performance of this research.

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Oleinik, I.I., Yagodinskii, V.N. The deliberate cultivation of antitumor properties in bacteria. Bull Exp Biol Med 48, 1396–1399 (1959). https://doi.org/10.1007/BF00788356

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  • DOI: https://doi.org/10.1007/BF00788356

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