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The effect of the titer of immune antibodies on the growth of tumor and normal tissues in vitro

  • Microbiology and Immunity
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The tissue of subcutaneous form of Ehrlich's adenocarcinoma (explant 1284) and the spleen of a white mouse (explant 1191) were cultured in vitro on nutrient media containing normal or immune antitumor, antisplenic and antihepatic sera of low and high titers. The results of this work demonstrate that sera with high titer of specific antibodies retard the appearance of manifestations of growth and affect its intensity in the explants of corresponding tissues. Low titer sera do not possess these properties. On the contrary, antitumor sera with a low content of specific antibodies have a growth stimulating effect on the tissues of Ehrlich's adenocarcinoma.

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Literature Cited

  1. V. S. Korosteleva, Problems of Immunology of Normal and Malignant Tissues, Original Russian pagination. See C. B. Translation. Moscow, pp. 94–104 (1956).

  2. M. S. Lomakin, Biull. Ekptl. Biol. i Med., No. 9, pp. 40–44 (1956). Original Russian pagination. See C. B. Translation.

    Google Scholar 

  3. I. N. Maiskii, The Biologic Basis of Anticancer Immunity, Original Russian pagination. See C. B. Translation. Moscow, pp. 27 (1955).

  4. G. V. Suvorova, Biull. Eksptl. Biol. i Med., No. 11, pp. 58–61 (1953).

    Google Scholar 

  5. G. V. Suvorova, Ibid., No. 12, 62–64 (1953).

    Google Scholar 

  6. A. D. Timofeevskii, Explantation of Human Tumors, Original Russian pagination. See C. B. Translation. Moscow, p. 136 (1947).

  7. P. P. Filatov, “Antimetastatic Action of Immune Antitumor Sera Under Experimental Conditions”, Thesis, Moscow (1956); Thesis, Moscow (1957).

  8. K. Fellinger, Arch. exper. Zellforsch., Bd. 13, S. 310–319 (1933).

    Google Scholar 

  9. D. Imagava, Proc. Am. Ass. Canc. Res. v. 1, p. 26 (1953).

    Google Scholar 

  10. D. T. Imagava, J. T. Syverton and J. Bittner, J. Cancer Res. v. 14, pp. 8–11 (1954).

    Google Scholar 

  11. R. Ludford, J. Arch. exper. Zellforsch. Bd. 14, S. 42–55 (1933).

    Google Scholar 

  12. T. Lumsden, Am. J. Canc. v. 15, pp. 563–640 (1931).

    Google Scholar 

  13. T. Lumsden, T. F. Macrae and E. Skipper, J. Path. a. Bact. v. 39, pp. 595–607 (1934).

    Google Scholar 

  14. H. J. Phelps, Am. J. Canc. v. 31, pp. 441–445 (1937).

    Google Scholar 

  15. K. Takeda, Gann. Japan J. Res. v. 46, N. 4, pp. 567–584 (1955).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Noninfectious Immunology Institute of Experimental Biology, Academy of Medical Sciences, USSR, Moscow

    G. V. Suvorova

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  1. G. V. Suvorova
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Suvorova, G.V. The effect of the titer of immune antibodies on the growth of tumor and normal tissues in vitro. Bull Exp Biol Med 46, 1112–1115 (1958). https://doi.org/10.1007/BF00787946

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  • DOI: https://doi.org/10.1007/BF00787946

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