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Changes in the interoceptive reflexes in dogs under the influence of narcotics

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments were performed on dogs without their preliminary narcotization. The author studied the effect of various anesthetics on the reflex changes of the blood pressure occurring in interoceptive stimulation. Phasic changes were noted in interoceptive reflexes with the increase of the doses of anesthetics (at first they increased and later decreased, became depressed and inversed).

In fractional administration of urethane (especially after the preliminary inhalation of ether) the period of normalization of the reflexes was noted. By this urethane differs from other anesthetics.

Is is assumed that the depressing effect of the anesthetic on the interoceptive reflexes (especially in the administration of chloral hydrate and sodium amytal) plays the main role in the mechanism of sleep therapy in clinical conditions.

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Authors and Affiliations

  1. Laboratory of Pathological Physiology of the I. P. Pavlov Institute of Physiology, AN SSSR, Leningrad

    T. V. Popova

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  1. T. V. Popova
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Deceased.

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Popova, T.V. Changes in the interoceptive reflexes in dogs under the influence of narcotics. Bull Exp Biol Med 47, 324–328 (1959). https://doi.org/10.1007/BF00787783

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  • DOI: https://doi.org/10.1007/BF00787783

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