Summary
Hypothalamic stimulation repeated many times over a long period in albino rats produced one of two different effects on the growth of grafted 45 and M-1 sarcomas. If the stimulation preceded the transplantation, the growth of the tumor was suppressed, and the tumor might even be completely absorbed. If stimulation followed the transplantation, tumor growth was intensified. A number of hypothalamic nervous structures were involved.
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Literature Cited
Yu. N. Bordyushkov, L. Kh. Garkavi, V. K. Goncharova, and others, Abstracts of Reports of the Sectional Session of the 9th Congress of the All-Union Society of Physiologists, Biochemists, and Pharmacologists, Minsk, Vol. 1, p. 97 (1959).
Yu. N. Bordyushkov and L. Kh. Garkavi, in book: Abstracts of Reports of the 13th Conference of Physiologists of Southern RSFSR. Rostov-on-Don, p. 18 (1960).
R. E. Kavetskii, The Tumor Process and the Nervous System. Kiev (1958).
V. P. Konoplev, in book: Models and Methods of Experimental Oncology, Moscow, p. 144 (1960).
L. V. Latmanizova, Research Reports of Leningrad Pedagogical Institute, Vol. 20, No. 8, p. 1 (1956).
Sh. D. Moshkovskii, Med. parazitol., Vol. 5, No. 5, p. 713 (1936).
M. K. Petrova, The Role of a Functionally Impaired Cerebral Cortex in the Development of Various Pathological Processes in the Organism. Leningrad (1946).
A. A. Solov'ev, Vopr. onkol., No. 1, p. 3 (1960).
M. A. Ukolova and Yu. N. Bordyushkov, Byull. éskper. biol., No. 8, p. 126 (1958).
M. A. Ukolova, in book: Reports of the 8th Scientific Conference of the Rostov Institute of Roentgenology, Radiology, and Oncology. Nal'chik, p. 24 (1959).
M. A. Ukolova, in book: Reports of the Rostov Regional Conference on the Protection of Health of Women, Rostov-on-Don, p. 36 (1960).
M. A. Ukolova, in book: Reports of the Scientific Conference on Problems of the Mechanisms of Cortico-Visceral Relationships (Abstracts of Reports) Baku, p. 266 (1960).
V. S. Sheveleva, Byull. éksper. bio., No. 10, p. 69 (1959).
R. Coujard and J. Chevreau, C. R. Acad. Sci. (Paris) Vol. 244, p. 2434 (1957).
E. Fifkova and J. Marsal, Stereotaxie podkorovych struktur mozku krysy, kralika a kocky, Praha (1960).
W. J. S. Krieg, Quart. Bull. Northw. Univ. med. Sch., Vol. 20, p. 199 (1946).
R. Schrek, Quoted by G. L. Zhdanov, in book: Models and Methods of Experimental Oncology, Moscow, p. 201 (1960).
G. Selye, Outlines of the Adaptation Syndrome. [in Russian] Moscow (1960).
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Ukolova, M.A., Bordyushkov, Y.N. & Garkavi, L.K. The effect of hypothalamic stimulation on the growth transplanted sarcomas. Bull Exp Biol Med 53, 588–591 (1963). https://doi.org/10.1007/BF00786752
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DOI: https://doi.org/10.1007/BF00786752