Abstract
Hypothalamic regulatory hormones are used in diagnostic procedures and for therapy, usually modified by chemical synthesis to enhance activities (Reichlin et al. 1976). The existence of regulators of anterior pituitary function, postulated many years ago (Bargmann 1949; Scharrer and Scharrer 1954), was experimentally demonstrated for the first time by Saffran and Schally (1955) in experiments utilizing hypothalamic and neurohypophyseal extracts. TRH was the first hypothalamic hormone whose chemical structure was elucidated (Bøler et al. 1969; Schally et al. 1970). Its main use is as a diagnostic instrument in thyroid disorders, pituitary tumors, and infertility.
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References and Further Reading
Thyrotropin-Releasing Hormone (TRH)
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Central Effects and Actions of CRH
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In Vitro Assay for CRH Activity
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Sandow, J. (2016). Hypothalamic Hormones. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Cham. https://doi.org/10.1007/978-3-319-05392-9_83
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DOI: https://doi.org/10.1007/978-3-319-05392-9_83
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-05391-2
Online ISBN: 978-3-319-05392-9
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences