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Hormone-induced changes in grafted rat mammary gland tumors (RMK-1)

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made of the reactivity to various hormones of the 2nd to 32nd generation of spontaneous rat mammary carcinoma (RMK-1) transplanted into randomly bred weanling rats. After the 10th generation, RMK-1 lost its reactivity to ovariectomy and hexestrol therapy, and became less sensitive to ovariectomy combined with adrenalectomy and cortisone treatment, as well as to ovariectomy combined with hexestrol and cortisone treatment. The loss of reactivity of RMK-1 to some hormones during repeated transplantations demonstrates that transplantable mammary cancers should not be used as an experimental model on which to base clinical methods of hormone therapy for this particular tumor.

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Authors and Affiliations

  1. Laboratory of Experimental Hormone Therapy Institute of Experimental and Clinical Oncology, AMN SSSR, Moscow

    N. D. Lagova

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  1. N. D. Lagova
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Lagova, N.D. Hormone-induced changes in grafted rat mammary gland tumors (RMK-1). Bull Exp Biol Med 53, 585–587 (1963). https://doi.org/10.1007/BF00786751

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  • DOI: https://doi.org/10.1007/BF00786751

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