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The effect of strophanthin-K on the activity of the myocardial sulfhydryl groups

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Theissue deals with the effect of strophanthin-K on the function of the isolated frogheartin conditions of selective blocking of sulfhydryl groups of cardiac muscle proteins by means of cadmium chloride. In such conditions strophanthin restored the cardiac contractions in all the experiments. The effect of urea and ATP was tested during sharp depression of the cardiac activity, caused by prolonged strophanthin perfusion. As a rule urea gave no effect, whereas ATP completely restored the amplitude of cardiac contractions. The ATP sensitivity lost by the cardiac muscle, may be restored by a brief action of strophanthin on the cardiac muscle. A suggestion was put forward that an important role in the mechanism of strophanthin effect on the contractility and the ATP activity of the cardiac muscle is played by an increased sulfhydryl group activity.

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Authors and Affiliations

  1. Pyatigorsk Clinic, Institute of Balneological Research at the Caucasian Mineral Waters, USA

    A. G. Saakyan & M. I. Kazanchev

Authors
  1. A. G. Saakyan
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  2. M. I. Kazanchev
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Saakyan, A.G., Kazanchev, M.I. The effect of strophanthin-K on the activity of the myocardial sulfhydryl groups. Bull Exp Biol Med 53, 560–563 (1963). https://doi.org/10.1007/BF00786745

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  • DOI: https://doi.org/10.1007/BF00786745

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