Skip to main content
SpringerLink
Log in

The action mechanism of certain anticholinesterase preparations

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

An inquiry was made into the time correlation of changes occurring in the muscular power with humoral shifts (adrenalin-like substances, pseudo and true cholinesterase) in myasthenia patients subjected to the administration of anticholinesterase preparations: briefly acting proserin and oxamysil — a preparation with a prolonged effect. There was no complete parallelism in the time of appearance of the antimyasthenic and anticholinesterase shifts. A rise of adrenalin-like substances in these conditions precedes the rise of the muscular power and cholinesterase inhibition, which may point to the activating effect of proserin and oxamysil on the sympathetic nervous system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. N. I. Grashchenkov, Nevropatol, i psikhiatr., Vol. 15, No. 1, p. 53 (1946).

    Google Scholar 

  2. É. Sh. Matlina, Labor. delo, No. 5 (1962).

  3. É. Sh. Matlina and V. M. Prikhozhan, in: Questions of the physiology and pathology of the endocrine glands (Abstracts of reports). Khar'kov, p. 73 [in Russian] (1961).

  4. É. Sh. Matlina and V. M. Prikhozhan, Labor. delo. No. 6, p. 10 (1961).

    Google Scholar 

  5. L. B. Perel'man and É. Sh. Matlina, Uspekhi sovr. biol. Vol. 46, No. 11, p. 46 (1958).

    Google Scholar 

  6. G. D. Smirnov, Dokl. AN SSSR, Vol. 58, No. 4, p. 689 (1947).

    Google Scholar 

  7. A. M. Utevskii, in: Questions of the biochemistry of the nervous system [in Russian] Kiev p. 131 (1957).

  8. W. Hardegg, E. Rieken, and H. Schmalz, Pflüg. Arch. ges. Physiol Bd. 259, S. 317 (1954).

    Google Scholar 

  9. A. G. Karczmar, J. Pharmacol. exp. Ther., Vol. 119, p. 39 (1957).

    Google Scholar 

  10. L. O. Randall and G. Lehmann, Ibid, Vol. 99, p. 16 (1950).

    Google Scholar 

  11. W. Riker, Jr., and W. C. Wescoe, Ibid., Vol. 88, p. 58 (1946).

    Google Scholar 

  12. M. B. Walker, Lancet, Vol. 226, p. 1200 (1934).

    Google Scholar 

  13. A. Wilson, G. A. Maw, and H. Geoghegan, Quart. J. Med., Vol. 20, p. 13 (1951).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Neurohumoral Regulation of the AN SSSR Institute of Higher Nervous Activity, Moscow

    L. B. Perel'man, V. M. Prikhizhan & É. Sh. Matlina

  2. Clinic of Nervous Diseases of the 1st Moscow Medical Institute, Moscow

    L. B. Perel'man, V. M. Prikhizhan & É. Sh. Matlina

Authors
  1. L. B. Perel'man
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. M. Prikhizhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. É. Sh. Matlina
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Perel'man, L.B., Prikhizhan, V.M. & Matlina, É.S. The action mechanism of certain anticholinesterase preparations. Bull Exp Biol Med 53, 555–559 (1963). https://doi.org/10.1007/BF00786744

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00786744

Keywords

Search

Navigation