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The ganglioplegic properties of aminazine (largactil) and mepazine (Pacatal)

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The preganglionic sympathetic trunk of the cat was stimulated by rectangular electric shocks of 20 cps frequency, and the contractions of the nictitating membrane and the biocurrents of the postganglionic fibers of the superior cervical ganglion were simultaneously recorded: neither aminazine (largactil) nor mepazine (pacatal) in doses of 5–10 mg/kg exerts any ganglioplegic effect. Sympatholytic properties of aminazine are more pronounced than those of mepazine.

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Literature Cited

  1. I. P. Anokhina, Zhur. Nevropatol. i Psikhiat., vol. 56, No. 6, pp. 478–488 (1956).

    Google Scholar 

  2. Yu. I. Vikhlyaev and G. I. Chugunov, in the book: abstracts of Papers Presented at the Conference on the Problem of the Link between the Structure and Effect of Medicinal Substances, Tartu, pp. 23–24 (1956). In Russian.

  3. M. D. Mashkovsky, S. S. Liberman and A. I. Polezhaeva, Farmakol. i Toksikol., vol. 18, No. 1; pp. 14–22 (1955).

    Google Scholar 

  4. H. Budde and E. Witzleb, Arch. inf. pharmacodyn., vol. 102, No. 1–2, pp. 126–138 (1955).

    Google Scholar 

  5. S. Courvoisier, I. Fournel, R. Ducrot, M. Kolsky, and P. Koltcshet, Arch. int. pharmacodyn, vol. 92, pp. 305–361 (1955).

    Google Scholar 

  6. P. Decourt, M. Brunaud, and S. Brunaud, Compt. rend. soc. biol. vol. 147, pp. 1602–1605 (1953).

    Google Scholar 

  7. M. Holzbauer and M. Vogr, Brit. J. Pharmacol., vol. 9, pp. 402–407 (1954).

    Google Scholar 

  8. F. Huidobro, Arch. int. pharmacodyn, vol. 98, No. 3, pp. 308–319 (1954).

    Google Scholar 

  9. H. Kewitz, Arch. exp. path. u. pharmakol., Bd. 222, S. 323–329 (1954).

    Google Scholar 

  10. H. Kopera, Wien. klin. Wschr., 67, N. 45, S. 867–874 (1955).

    Google Scholar 

  11. Idem. Ibid, No. 46, S. 887–892, (1955).

    Google Scholar 

  12. H. Laborit and P. Huguenard, Presse med., ann. 59, No. 64, pp 1329–1329, (1951).

    Google Scholar 

  13. H. Laborit, P. Huguenard, and P. Alluame. Presse med., No. 10, pp. 206–208 (1952).

    Google Scholar 

  14. O. Nieschulz, R. Popendiker and I. Hoffmann, Arzneimit.-Forsch., No. 2, S. 680–695 (1955).

    Google Scholar 

  15. A. Quevauviller, Produits pharm., vol. 10, No. 3, pp. 175–182 (1955).

    Google Scholar 

  16. I. I. Reuse, Compt. rend. soc. biol. vol. 148, pp. 192–193 (1954).

    Google Scholar 

  17. H. Ruppert, Zbl. Gynakol., 77, No. 7, S. 250–256 (1955).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Special Pharmacology, Institute of Pharmacology and Chemotherapy of the Academy of Medical Sciences of the USSR, Moscow

    D. A. Kharkevich

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  1. D. A. Kharkevich
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Kharkevich, D.A. The ganglioplegic properties of aminazine (largactil) and mepazine (Pacatal). Bull Exp Biol Med 43, 188–190 (1957). https://doi.org/10.1007/BF00786356

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  • DOI: https://doi.org/10.1007/BF00786356

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