Summary
The agglutinin content of the blood of newborn and their mothers was studied in order to investigate the problem of the transplacental passage of antibodies.
The investigations were carried out post partum in a lying-in hospital. There were observed 100 mothers and the same number of newborn. The results were checked experimentally in female rabbits and their offspring.
It was established that transplacental passage of agglutinins from mother to fetus takes place. However, the titers of antibodies in the blood of the newborn were, as a rule, lower than the corresponding titers in the maternal blood. Consequently this passage of antibody cannot be considered to be simple filtration of antibodies through a semipermeable membrane.
Similar content being viewed by others
Literature Cited
E. R. Pille. Increased Immunoreactivity in Experimental Influenza Infections, Diss., In Russian Moscow, 1952.
H. Bourquin, Am. J. Physiol., 1922, Vol. 59, pp. 122–143.
A. Kuttner and B. Ratner, Am. J. Diss. Child., 1923, Vol. 25, pp. 413–434.
P. Römer, Berl. klin. Wschr., 1901, Vol. 38, No. 46, p. 1150.
I. Smith and A. Holm, J. Biol. Chem., 1948, Vol. 175, No. 1, pp. 349–365.
H. Rupp, Arch. f. Gyn., 1930, Vol. 143, pp. 80–145.
I. Smith and R. B. Little, J. Exper. Med., 1923, Vol. 37, p. 671.
J. A. Toomey, Am. J. Dis. Child, 1934, Vol. 47, pp. 521–528.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rabinovich, S.A. Experimental investigation of the passage of agglutinins from mother to fetus. Bull Exp Biol Med 45, 78–82 (1958). https://doi.org/10.1007/BF00785981
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00785981