Summary
In normal atropinized and chronically desympathetized frog heart the effect of vagus nerve stimulation is altered but not excluded.
Stimulation of the nuclei of the vagus nerve in the medulla oblongata causes a constant sympatheticomimetric effect. The same is to be seen in chronically desympathetized frogs. During atropinization and washing the negative chronotropic effect caused by vagus stimulation was replaced by a positive one. The last to be altered was the reaction of the heart to acetylcholine.
The atropinized heart secretes more vagus substances than the normal one.
Stimulation of the vagus nuclei after atropinization causes a slight diminution of the resting potential of the heart muscles, diminishing at the same time the amplitude of monophase action potentials.
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Keder-Stepanova, M.A. Iono-humoral interrelations during the appearance and development of vagal inhibition of the heart. Bull Exp Biol Med 43, 530–534 (1957). https://doi.org/10.1007/BF00785731
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DOI: https://doi.org/10.1007/BF00785731