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Distribution of carcinogenic dialkylhydrazines-3H in the neuroendocrine system and their antigonadotropic effect in rats

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Three hours after injection of dimethylhydrazine (DMH)-3H into male rats the specific radioactivities of the pituitary, adrenal cortex, and testes were 53, 85, and 108% higher, respectively, than of the liver. Incorporation of the isotope into the hypothalamus was 33% greater than into the liver, and 69 and 44% greater, respectively, than into the cerebral cortex and brain stem. Three hours after injection of diethylhydrazine (DEH)-3H into male rats the specific radioactivities of the pituitary and testes were 57 and 108% higher, respectively, than that of the liver. A single injection of DMH or DEH in a dose of 21 mg/kg into male rats led to a significant decrease in the content of follicle-stimulating hormone (FSH) in the pituitary (by 63 and 53%, respectively). The results are evidence that carcinogenic dialkylhydrazines have a marked effect on the neuroendocrine system in rats.

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Authors
  1. V. N. Anisimov
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  2. M. A. Azarova
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  3. A. Yu. Dmitrievskaya
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  4. A. Ya. Likhachev
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  5. A. S. Petrov
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  6. Ya. D. Shaposhnikov
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Anisimov, V.N., Azarova, M.A., Dmitrievskaya, A.Y. et al. Distribution of carcinogenic dialkylhydrazines-3H in the neuroendocrine system and their antigonadotropic effect in rats. Bull Exp Biol Med 82, 1840–1842 (1976). https://doi.org/10.1007/BF00785713

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  • DOI: https://doi.org/10.1007/BF00785713

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