Summary
Disturbance of cholesterol metabolism occurred in experimental lead intoxication. In rabbits subjected to the action of lead alone this derangement was manifested in reduced stability of the cholesterol-protein bond and some tendency to the rise of the total cholesterol and protein-nonbound cholesterol content. In rabbits which received cholesterol in combination with lead acetate, the content of total cholesterol, protein-nonbound, and loosely protein-bound cholesterol is much greater than in rabbits which were given the same amount of cholesterol without lead. The results obtained led to an assumption that reduced stability of the cholesterol-protein bond represented the first stage of cholesterol metabolism disturbance under the effect of lead.
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Konikova, G.S. Cholesterol metabolism in experimental lead poisoning. Bull Exp Biol Med 54, 1246–1248 (1963). https://doi.org/10.1007/BF00785598
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DOI: https://doi.org/10.1007/BF00785598