Abstract
The development of toxic manifestations in rats exposed to hyperoxia is accompanied by a significant decrease in the activity of erythrocytic superoxide dismutase (SOD). Incubation of hemolysates from control animals with H2O2 (10−3 M) or cumene peroxide (1.6\10−4 M) also led to a marked decrease in the initial SOD activity. The decrease in the initial SOD activity during hyperoxia is thus evidently connected with the formation of peroxidation products in the cells.
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Mikhailov, Y.E., Gerasimov, A.M., Gusev, V.A. et al. Erythrocyte superoxide dismutase activity in rats subjected to a toxic regime of intermittent hyperbaric oxygenation. Bull Exp Biol Med 82, 1196–1198 (1976). https://doi.org/10.1007/BF00785555
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DOI: https://doi.org/10.1007/BF00785555