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The effect of strophanthin on the coronary circulation and cardiac oxygen intake in experimental myocarditis

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Strophanthin given in therapeutic doses to healthy animals has no significant effect upon the coronary circulation and oxygen intake by the cardiac muscle. Toxic doses reduce the coronary circulation, the cardiac oxygen intake and the blood pressure; bradycardia appears. The dose of 20 μg/kg, which causes no changes in the coronary blood flow or the cardiac oxygen intake in the healthy animals, considerably reduces these values in animals with experimentally induced myocarditis. The different qualitative reactions occurring in response to strophanthin administration to animals with experimentally induced myocarditis may be partially explained by the increased cardiac sensitivity to strophanthin in this condition and the intensified excitation of the vagus nerves; the reflex character of the latter effect follows from experiments with vagotomy.

The data on the increase in strophanthin toxicity and the different qualitative reaction of the coronary circulation observed in experimental myocarditis should be taken into consideration by clinicians treating diseases of the cardio vascular system with cardiac glycosides.

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Authors and Affiliations

  1. Department of Pharmacology of the I. M. Sechenov Order of Lenin 1st Moscow Medical Institute, Moscow, USSR

    E. A. Veselova

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  1. E. A. Veselova
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Veselova, E.A. The effect of strophanthin on the coronary circulation and cardiac oxygen intake in experimental myocarditis. Bull Exp Biol Med 50, 1283–1288 (1961). https://doi.org/10.1007/BF00785385

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  • DOI: https://doi.org/10.1007/BF00785385

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