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The local reflex component in the cardiac response to raised intrapulmonary pressure and to increased pressure in the vena cava

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments were performed on canine heart-lung preparations. Injections were given into the coronary circulation of 0.1–2 mg/kg body weight of arphonade, a ganglion-blocking agent which depresses local viscerovisceral reflexes; it was found that cardiac reactions to increased blood pressure in the vena cava (Starling's Law) and to a rise of intrapulmonary pressure were depressed. Injecting 5–10 mg/kg body weight of cysteine, which is a sulfhydryl-group donor partially restored the initial reactions. The results obtained indicate that local reflexes play an important part in the reactions described.

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Literature Cited

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Authors and Affiliations

  1. Laboratory of Circulation and Respiration AN SSSR Institute of Physiology and Laboratory of Pharmacology Institute of Experimental Biology and Medicine Siberian Division, AN SSSR, Siberian, USSR

    O. M. Gal'perin & A. I. Briskin

Authors
  1. O. M. Gal'perin
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  2. A. I. Briskin
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Gal'perin, O.M., Briskin, A.I. The local reflex component in the cardiac response to raised intrapulmonary pressure and to increased pressure in the vena cava. Bull Exp Biol Med 50, 1243–1245 (1961). https://doi.org/10.1007/BF00785376

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  • DOI: https://doi.org/10.1007/BF00785376

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