Summary
The author studied the effect of phthivazid and tubazid on some physiological functions of rabbits.
It was found that phthivazid, administered per os to healthy animals for a long period of time, promotes parasympathomimetic shifts in the mediator system, has no effect on the blood sugar leve, and possesses a glycogen-forming effect, thus evidently limiting the accumulation of fat in the liver.
Under the same conditions tubazid evokes a pronounced sympathomimetic effect, increases the blood sugar level, reduces the glycogen content in the muscles and liver, and promotes fat accumulation in the liver.
The difference in the action of these two preparations on the body suggests that phthivazid has an advantage over tubazid due to its more sparing physiological effect.
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Izabolinskaya, R.M., Kogosova, L.S. Experimental data on the effect of phthivazid and tubazid on the body. Bull Exp Biol Med 48, 1242–1245 (1959). https://doi.org/10.1007/BF00785181
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DOI: https://doi.org/10.1007/BF00785181